Category: Pregnane X Receptors

The authors demonstrate that adaptive as well as acquired resistance to the EGFR inhibitor serlotinib, a TKI of EGFR, converged on MAPK activation

The authors demonstrate that adaptive as well as acquired resistance to the EGFR inhibitor serlotinib, a TKI of EGFR, converged on MAPK activation.38 The rationale of combining the ErbB family inhibitor Afatinib with MEK inhibitor PD-901 has been recently demonstrated by Lin et al. Results ERK1/2 phosphorylation was rebounded...

For example, in a series of publications, Huang co-delivery of siRNA and anticancer drugs (194,197,198)

For example, in a series of publications, Huang co-delivery of siRNA and anticancer drugs (194,197,198). Another common approach involves the direct complexation of anionic oligonucleotides with cationic molecules that have some degree of endosome escape capability inherent in their chemistry. advent of antisense and siRNA oligonucleotides sparked high hopes...

XJD, YL participated in the design of this study, carried out all the studies, performed the statistical analysis and drafted the manuscript, XLL carried out partial infection experiments

XJD, YL participated in the design of this study, carried out all the studies, performed the statistical analysis and drafted the manuscript, XLL carried out partial infection experiments. of cellular cholesterol with MCD had no apparent effect on PRV adsorption; however, depletion of cholesterol significantly restricted entry and post-entry...