A 3.3 fold increase in the ratio of reduced BH4 to oxidized pterins was seen in BH4 fed DOCA-salt animals as compared to hypertensive mice without BH4 feeding (p=NS; Figure 3, d). cardiac BH4 stores, phosphorylated phospholamban levels, and diastolic dysfunction. Isolated cardiomyocyte experiments revealed impaired relaxation that was...