Several reports mentioned the important role of humoral immunity in controlling the exitance period of coronavirus infection[24-26]
Several reports mentioned the important role of humoral immunity in controlling the exitance period of coronavirus infection[24-26]. its significant effects on immunity, pulmonary functions, and COVID-19 risk factors. A mild to moderate cycling or walking with 60%-80% Vo2max for 20-60 min performed 2-3 times per week could be a safe and effective aerobic exercise program in patients with COVID-19 to enhance their immunity and pulmonary functions. Keywords: Oxygenation, COVID-19, Immunity, Pulmonary functions, Psycho-immune hormones, COVID-19 risk factors Core Tip: Coronavirus disease 2019 is a self-limited infection, and interventions that can increase immunity are strongly recommended. Thus, enhancing oxygenation is one of the safe and effective interventions in enhancing immunity and pulmonary functions. This review discusses the possible effects of enhancing oxygenation of patients with coronavirus disease 2019 on immunity and other health-related conditions. INTRODUCTION The coronavirus or coronavirus disease 2019 (COVID-19) is defined by the World Health Organization as a world disaster. The World Health Organization has announced that through February 11, 2021 that there were 106797721 confirmed cases, among them 2341145 deaths[1]. COVID-19 is recognized as a surrounded RNA beta-coronavirus commonly identified as the severe acute respiratory syndrome coronavirus 2[2]. Communal signs of COVID-19 include cough and fever[3]. Fever presents in 43.8% of patients with COVID-19 on early admission; though, it rises ZM-241385 to 88.7% throughout hospitalization. The next communal symptom is cough, which happens in approximately 67.8%[2]. Other symptoms contain fatigue, dyspnea, and myalgia. COVID-19 has been demonstrated to be self-limited where the hosts immune strength plays a ZM-241385 key role in decreasing its associated disorders and death rates[4]. Thus, interventions that increase immune functions are strongly needed to either people in lockdown or people with COVID-19. Enhancing oxygenation has been demonstrated as a safe and effective intervention to increase immune functions. The advantage of enhancing oxygenation over other interventions is that it causes an autonomic modulation; this autonomic modulation increases pulmonary functions and controls pyscho-immune changes that occur due to ILK high stressors (such as COVID-19). Thus, this review highlights the influence of enhancing oxygenation on immunity, pulmonary functions, psycho-immune hormones, and obesity. Also, this review highlights the defensive role of enhancing oxygenation on COVID-19 risk factors. THE INFLUENCE OF ENHANCING OXYGENATION ON IMMUNITY AMONG PATIENTS WITH ZM-241385 COVID-19 The strength of immunity plays a fundamental role in the treatment of any infection. COVID-19 is a self-limited infection; thus, strengthening immunity might have a significant role in lessening its associated disorders and death rates[5]. However, the existence of some vaccines, the development of specific drugs to treat patients with COVID-19 could continue for about 1 year. Therefore, the need for a fast and safe treatment for COVID-19 is definitely a necessity to reducing its connected disorders and death rates. Enhancing oxygenation can afford a safe and immediate enhancement in immunity strength[5]. This subtopic discusses the vital role of enhancing oxygenation on enhancing COVID-19 specified immunity components vital for decreasing connected disorders and death rates. Immunity primarily divides into two parts, including immune cells and humoral immunity. The effects of increasing the oxygenation on immunity are illustrated in Number ?Figure11. Open in a separate window Number 1 Effect of increasing the aerobic capacity on immunity. This diagram illustrates possible mechanisms of increasing oxygenation capacity in ZM-241385 improving the immunity. These possible mechanisms include increasing the function and activity of immune cells, immunoglobulins, and pentraxins. COVID-19: Coronavirus disease 2019; Ig: Immunoglobulin; IL: Interleukin; NK: Natural killer; TNF-: Tumor necrosis factor-alpha. The influence of enhancing oxygenation on immune cells The 1st immunity component that fights COVID-19 infection is definitely immune cells. COVID-19, severe acute respiratory syndrome coronavirus, and Middle East respiratory syndrome coronavirus are -coronavirus subtypes, which could lead to severe lower respiratory tract and extrapulmonary symptoms[6,7]. T-lymphocytes, among all immune cells, have a.